The complication frequently accompanying diabete, uch a impairment of viion and of kidney function, are now thought to reult from the lack of continuou control of blood glucoe concentration. The healthy pancrea, in repone to increae in blood glucoe concentration, releae mall quantitie of inulin throughout the day and thereby maintain the concentration within phyiological limit . But the diabetic generally receive only one large doe daily. The diabetic blood glucoe concentration can thu fluctuate greatly during the interval between doe, and it ha been uggeted that the complication reult from the period of high concentration of blood glucoe . Many invetigator thu believe that retoration of normoglycemia might halt the progreion of uch complication and perhap even revere them.
There are three primary technique that have been invetigated for retoration of normoglycemia. They are: tranplantation of whole, healthy pancreae; tranplantation of ilet of Langerthan, that portion of the pancrea that actually ecrete inulin, and implantation of artificial pancreae. There ha, in fact been a great deal of ucce in the development of thee technique and each eem, on the whole, promiing. Nonethele, it will undoubtedly be many year before any one of them i accepted a a treatment for diabete.
To many people, the obviou approach would eem to be imply to tranplant pancreae from cadaver in the ame manner that kidney and other organ are routinely tranplanted. That wa the rationale in 1966 when the firt recorded pancrea wa performed. Between 1960 and 1975, there were forty-ix pancrea tranplant in forty-five other patient in the United State and five other countrie. But only one of thee patient i till alive with a functioning graft and urgeon have found that the procedure i not imple a they once thought.[由wwW.HaoZuoWen.com整理]